Medetomidine hydrochloride should be administered at the rate of 750 mcg iv or mcg im per square meter of body surface. The chemical name is 42ethyl2,3dihydro1hinden2yl1himidazole hydrochloride. Domitor medetomidine hydrochloride is a synthetic alpha 2. Medetomidine hydrochloride mpv785 cas 86347151 abmole.
Dexmedetomidine hydrochloride united states pharmacopeia. Medetomidine hydrochloride cas 86347151 scbt santa cruz. Msds shows how the material reacts to environment and how to store it properly. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Role of alpha2adrenoceptors and glutamate mechanisms in the external urethral sphincter continence reflex in rats. Sixtyfour dexmedetomidine hydrochloridetreated dogs and 50 medetomidine treated dogs were observed with bradycardia. Ketamine hydrochloride injection, usp respiratory protection respiratory protection is not needed during normal product use. View and buy high purity medetomidine hydrochloride from tocris bioscience. Specification of medetomidine hcl test specifications results appearance white or. Medetomidine hydrochloride supplier cas 86347151 tocris.
Medetomidine administered parenterally results in a dose. Anaesthetic effects of medetomidine hcl with propofol, ketamine and chloral hydrate in equines h. Dexmedetomidine hcl decreases sympathetic nervous system activity and has the potential to augment bradycardia induced by vagal stimuli. Medetomidine hydrochloride ch17cln2 cid 68601 structure, chemical names, physical and chemical properties, classification, patents, literature. This product has been classified in accordance with the hazard criteria of the cpr and the msds contains all of the information required by the cpr. Cats were treated by im administration of saline 0. The molecular formula is c 14 h 16 n 2 hcl and structural. Dexmedetomidine hydrochloride injection safety data sheet sds. Eye protection eye protection is not required during expected product use conditions but may be warranted should a splash potential exist. In canada, medetomidine is distributed by novartis animal health. Evaluation of potential occupational exposures should include consideration of the dermal route. Medetomidine at the dose rate of 8g kg 1 produced moderate sedation in most animals, where as 10g kg 1 and 12g kg 1. An agonist of receptors, adrenergic alpha2 that is used in veterinary medicine for its analgesic and sedative properties.
Medetomidine impurity 28 hcl mixture of diastereomers c 23 h 28 n 2. Federal law restricts this drug to use by or on the order of a licensed veterinarian. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine oel fastrac with ade affygility solutions. Comparison of medetomidine and dexmedetomidine as premedicants in dogs undergoing propofolisoflurane anesthesia. Msds includes information such as melting point, boiling point, and flash point of a hazardous material. Medetomidine hcl was clinically evaluated as anesthetic at various doses on the basis of sedative, analgesic and. The effects of medetomidine hydrochloride on the electroretinogram of normal dogs article in veterinary ophthalmology 115. The molecular formula is c 14 h 16 n 2 hcl and structural formula is. Medetomidine, commonly known by the brand name dormitor, is an injectable drug used for sedation in dogs and cats. References are publications that support the biological activity of the product. Study the material safety data sheets for the hazards of the chemical, learn the instructions on handling, storage and the emergency measures in case of accident take our free online course to learn how to to properly apply and use your msds complete a full risk assessment for your workplace so that you can map out all the hazards into a single comprehensive coshh assessment.
Skin protection if solution contact with unprotected skin is likely, use of impervious gloves is a prudent practice. Virtanen et al 1988 characterization of the selectivity, specificity and potency of medetomidine as an. Death approximately 1 in 40,000 treatments has been noted in clinical use with doses at 2 times the recommended dose of medetomidine hydrochloride. Medetomidine is a synthetic drug used as both a surgical anesthetic and analgesic. Describes the effects when workers come into contact with the chemical and how to proceed in case of an accident.
Later on the efficacy of medetomidine hcl as preanesthetic was assessed by using it in combination with other drugs. It is a white, or almost white, crystalline, water soluble substance having a molecular weight of 236. Identification of the substancemixture and of the companyundertaking product name. Medetomidine is indicated for premedication for anesthetic procedures and for sedation. Medetomidine hydrochloride can be absorbed and may cause irritation following direct exposure to skin, eyes, or mouth. Medetomidine hydrochloride is a potent and highly selective. Domitor injectable solution medetomidine hydrochloride sterile. Inquire about dmf, cgmp, price, availability, samples, sourcing, purity and more. Dexmedetomidine hydrochloride injection safely and. Dispose of this material and its container to hazardous or special waste collection point. Inhibits twitch response in electrically stimulated mouse vas deferens pd 2 9. Dexdomitor is supplied in a multidose vial containing 10 ml of a sterile aqueous solution of 0. Kuusela e1, raekallio m, vaisanen m, mykkanen k, ropponen h, vainio o.
Hcl component approximate percent by weight cas number rtecs number. Proceduresthe 5 cats received each of 11 treatments. In the workplace, dexmedetomidine hydrochloride should be considered a potent drug. Apexbio medetomidine hcl javascript seems to be disabled in your browser. Medetomidine is the racemic mixture of the active denantiomer dexmedetomidine and the inactive lenantiomer. Hazardous toxic fumes of cl, hcl, and nitrogen oxides decomposition products hazardous not determined.
Antisedan atipamezole hydrochloride is a synthetic alpha 2 adrenergic antagonist. Dexmedetomidine is the active sisomer of medetomidine. Dexmedetomidine hydrochloride united states pharmacopeia usp. Pfizer msds for medetomidine hydrochloride sterile injectable solution occupational exposure potential published reports indicate that dexmedetomidine may be absorbed through intact skin. Please post your buying leads,so that our qualified suppliers will soon contact you. Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. In the united states, it is currently approved for its veterinary use in dogs and distributed by pfizer animal health. Bradycardia has also been reported in association with intravenous infusion of dexmedetomidine hcl. Objectiveto investigate doserelated diuretic effects of medetomidine hydrochloride and xylazine hydrochloride in healthy cats. Medetomidine is no longer commercially available and has been replaced by its racemic isomer dexmedetomidine dexdomitor. Medetomidine hydrochloride dosage and administration. In case of accidental eye exposure, flush with water for 15 minutes. Medetomidine is an imidazole derivative more potent than xylazine salonen, 1992.
Medetomidine is an intravenously available alpha2 adrenergic agonist. Im dexmedetomidine dogs had heart rates from 45 to 73 bpm, and im medetomidine dogs from 52 to 79 bpm. Bradycardia occurred within 5 to 15 minutes after iv dexmedetomidine hydrochloride or medetomidine, and within 15 to 30 minutes after either drug given im. It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid. Dexmedetomidine hydrochloride injection safely and effectively. Material safety data sheet of medetomidine hydrochloride contains identification of substance and details of the supplier of the safety data sheet. Incinerate the material under controlled conditions in an approved incinerator. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression. Material safety data sheet of medetomidine hydrochloride. Ingredients percent test type value units species ketamine hydrochloride 100 ld50 447670 mgkg rats mice ld50 is the dosage producing 50% mortality. Comparison of the diuretic effects of medetomidine. Animals5 sexually intact cats 4 males and 1 female. Selected citations for medetomidine hydrochloride include. For parenteral use in reversing and abolishing the effects of medetomidine hydrochloride in dogs and cats.
Dec 16, 2019 cardiac rhythms were evaluated by auscultation. Medetomidine is an equal mixture of two optical enantiomers, dexmedetomidine and levomedetomidine. Other information text of r phrases mentioned in section 3 r28 very toxic if swallowed. Medetomidine hydrochloride distributor buy 106807721. Noah compendium domitor 1 mgml solution for injection 01. The senantiomer, dexmedetomidine is used as the hydrochloride for sedation in intensive care and in surgical and medical procedures. To report adverse reactions in users or to obtain a copy of the msds for this product call 18889638471. Savola et al 1986 evidence for medetomidine as a selective and potent agonist at alpha 2adrenoceptors.
First aid measures description of first aid no data available. Anaesthetic effects of medetomidine hcl with propofol. Anjum department of clinical medicine and surgery, department of epidemiology and public health, department of microbiology, university of veterinary and animal sciences. Domitor sedative and analgesic for dogs and cats msds. Medetomidine hydrochloride msds download sevron safety software. See full prescribing information for dexmedetomidine hydrochloride injection. Hcl to young, healthy adult volunteers with high vagal tone or following rapid intravenous or bolus administration of dexmedetomidine hcl. Dexmedetomidine hydrochloride is a highly potent and selective. Formaldehyde, 37% ww safety data sheet according to federal register vol.
Bradycardia resolved more slowly in the im treatment groups. Noah compendium domitor 1 mgml solution for injection. Medetomidine hydrochloride cas 86347151 tocris bioscience. Dexmedesed dexmedetomidine hydrochloride is a synthetic alpha 2adrenoreceptor agonist with sedative and analgesic properties. Medetomidine belongs to a class of drugs known as alpha 2 adrenergic agonists and is similar to clonidine and xylazine.
Medetomidine hydrochloride safety data sheet section 2. Medetomidine is a potent nonnarcotic alpha 2adrenoreceptor agonist which produces sedation and. The sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Msds contains more detailed occupational safety information. The body temperature remained at the same level during the 120 minutes of followup after atipamezole administration. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves. Plumbs veterinary drugs, accessible on your tablet, smartphone, and computer, is continually updated so you have the most current information available to help you make more informed drug decisions. Medetomidine is a synthetic compound used as a surgical anesthetic and analgesic. The citations listed below are publications that use tocris products. Other alpha 2agonists include romifidine and detomidine, which are generally reserved for use in cattle and. Clinical pharmacology medetomidine is a potent nonnarcotic. Medetomidine hydrochloride cas 86347151 scbt santa. Buy adrenergic receptor inhibitor medetomidine hydrochloride mpv785 from abmole bioscience. Objectiveto investigate doserelated diuretic effects of medetomidine hydrochloride and xylazine hydrochloride in healthy cats animals5 sexually intact cats 4 males and 1 female proceduresthe 5 cats received each of 11 treatments.
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